3PPY
Crystal structure of the D1596A/N1602A double mutant of an engineered VWF A2 domain (N1493C and C1670S)
Summary for 3PPY
Entry DOI | 10.2210/pdb3ppy/pdb |
Related | 3GXB 3PPV 3PPW 3PPX |
Descriptor | von Willebrand factor, SODIUM ION (3 entities in total) |
Functional Keywords | von willebrand factor, vwa domain, and calcium, rossmann fold, blood coagulation, cell adhesion, protein unfolding, and adamts13 cleavage, glycosylation |
Biological source | Homo sapiens (human) |
Cellular location | Secreted : P04275 |
Total number of polymer chains | 1 |
Total formula weight | 21999.78 |
Authors | |
Primary citation | Zhou, M.,Dong, X.,Baldauf, C.,Chen, H.,Zhou, Y.,Springer, T.A.,Luo, X.,Zhong, C.,Grater, F.,Ding, J. A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13 Blood, 117:4623-4631, 2011 Cited by PubMed: 21385852DOI: 10.1182/blood-2010-11-321596 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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