3PP1

Crystal Structure of the Human Mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgATP

3PP1 の概要

• エントリーDOI: 10.2210/pdb3pp1/pdb
• 関連するPDBエントリー: 3MBL
• 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: kinase domain, kinase, atp binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q02750
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37734.98

構造登録者

Dougan, D.R. (登録日: 2010-11-23, 公開日: 2011-02-23, 最終更新日: 2024-02-21)

• 主引用文献: Dong, Q.,Dougan, D.R.,Gong, X.,Halkowycz, P.,Jin, B.,Kanouni, T.,O'Connell, S.M.,Scorah, N.,Shi, L.,Wallace, M.B.,Zhou, F.; Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer.; Bioorg.Med.Chem.Lett., 21:1315-1319, 2011; PubMed: 21310613; DOI: 10.1016/j.bmcl.2011.01.071

実験手法

X-RAY DIFFRACTION (2.7 Å)