3PO1
Thrombin in complex with Benzothiazole Guanidine
Summary for 3PO1
Entry DOI | 10.2210/pdb3po1/pdb |
Descriptor | Thrombin light chain, Thrombin heavy chain, thrombin peptide, ... (8 entities in total) |
Functional Keywords | serine protease, coagulation factor ii, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 P00734 |
Total number of polymer chains | 4 |
Total formula weight | 33563.35 |
Authors | |
Primary citation | Karle, M.,Knecht, W.,Xue, Y. Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV. Bioorg.Med.Chem.Lett., 22:4839-4843, 2012 Cited by PubMed: 22726924DOI: 10.1016/j.bmcl.2012.05.046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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