3PNH

Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in complex with 6-(((3R,4R)-4-(2-((2-FLUORO-2-(3-FLUOROPHENYL) ETHYL)AMINO)ETHOXY)PYRROLIDIN-3-YL)METHYL)-4-METHYLPYRIDIN-2-AMINE

3PNH の概要

• エントリーDOI: 10.2210/pdb3pnh/pdb
• 関連するPDBエントリー: 3PNE 3PNF 3PNG
• 分子名称: Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (9 entities in total)
• 機能のキーワード: heme enzyme, inhibitor, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Bos taurus (bovine,cow,domestic cattle,domestic cow)
• 細胞内の位置: Cell membrane : P29473
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 96848.14

構造登録者

Delker, S.L.,Li, H.,Poulos, T.L. (登録日: 2010-11-18, 公開日: 2011-10-05, 最終更新日: 2024-02-21)

• 主引用文献: Xue, F.,Kraus, J.M.,Labby, K.J.,Ji, H.,Mataka, J.,Xia, G.,Li, H.,Delker, S.L.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.; Improved Synthesis of Chiral Pyrrolidine Inhibitors and Their Binding Properties to Neuronal Nitric Oxide Synthase.; J.Med.Chem., 54:6399-6403, 2011; PubMed: 21809851; DOI: 10.1021/jm200411j

実験手法

X-RAY DIFFRACTION (1.93 Å)