3PLS

RON in complex with ligand AMP-PNP

3PLS の概要

• エントリーDOI: 10.2210/pdb3pls/pdb
• 分子名称: Macrophage-stimulating protein receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
• 機能のキーワード: protein kinase, cis autophosphorylation conformation, receptor tyrosine kinase, amp-pnp, unphosphorylated, single-span transmembrane receptor, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: Q04912
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34778.92

構造登録者

Wang, J.,Steinbacher, S.,Augustin, M.,Schreiner, P.,Epstein, D.,Mulvihill, M.J.,Crew, A.P. (登録日: 2010-11-15, 公開日: 2010-11-24, 最終更新日: 2024-02-21)

• 主引用文献: Wang, J.,Steinbacher, S.,Augustin, M.,Schreiner, P.,Epstein, D.,Mulvihill, M.J.,Crew, A.P.; The Crystal Structure of a Constitutively Active Mutant RON Kinase Suggests an Intramolecular Autophosphorylation Hypothesis; Biochemistry, 49:7972-7974, 2010; PubMed: 20726546

実験手法

X-RAY DIFFRACTION (2.24 Å)