3PJC

Crystal structure of JAK3 complexed with a potent ATP site inhibitor showing high selectivity within the Janus kinase family

3PJC の概要

• エントリーDOI: 10.2210/pdb3pjc/pdb
• 分子名称: Tyrosine-protein kinase JAK3, 3-(1H-indol-3-yl)-4-[2-(4-oxopiperidin-1-yl)-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrrole-2,5-dione (3 entities in total)
• 機能のキーワード: small molecule inhibitor, atp site kinase inhibitor, atp-binding, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endomembrane system; Peripheral membrane protein (By similarity): P52333
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36152.14

構造登録者

Tavares, G.A.,Thoma, G.,Zerwes, H.-G.,Kroemer, M. (登録日: 2010-11-09, 公開日: 2010-12-29, 最終更新日: 2024-02-21)

• 主引用文献: Thoma, G.,Nuninger, F.,Falchetto, R.,Hermes, E.,Tavares, G.A.,Vangrevelinghe, E.,Zerwes, H.G.; Identification of a Potent Janus Kinase 3 Inhibitor with High Selectivity within the Janus Kinase Family.; J.Med.Chem., 54:284-288, 2011; PubMed: 21155605; DOI: 10.1021/jm101157q

実験手法

X-RAY DIFFRACTION (2.2 Å)