3PJ2
Crystal structure of BTK kinase domain complexed with 2-[4-(2-Diethylamino-ethoxy)-phenylamino]-6-(4-fluoro-phenoxy)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one
Summary for 3PJ2
Entry DOI | 10.2210/pdb3pj2/pdb |
Related | 3PIX 3PIY 3PIZ 3PJ1 3PJ3 |
Descriptor | Tyrosine-protein kinase BTK, 2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-6-(4-fluorophenoxy)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (3 entities in total) |
Functional Keywords | helix c-out, dfg-in, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q06187 |
Total number of polymer chains | 1 |
Total formula weight | 32305.05 |
Authors | Kuglstatter, A.,Wong, A. (deposition date: 2010-11-08, release date: 2011-01-12, Last modification date: 2023-09-06) |
Primary citation | Kuglstatter, A.,Wong, A.,Tsing, S.,Lee, S.W.,Lou, Y.,Villasenor, A.G.,Bradshaw, J.M.,Shaw, D.,Barnett, J.W.,Browner, M.F. Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures. Protein Sci., 20:428-436, 2011 Cited by PubMed: 21280133DOI: 10.1002/pro.575 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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