3PIQ

Crystal structure of human 2909 Fab, a quaternary structure-specific antibody against HIV-1

Summary for 3PIQ

• Entry DOI: 10.2210/pdb3piq/pdb
• Descriptor: Human monoclonal antibody 2909 Fab heavy chain, Human monoclonal antibody 2909 Fab light chain (2 entities in total)
• Functional Keywords: monoclonal antibody, neutralizing, hiv-1, quaternary epitope, trimeric envelope spike, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 12
• Total formula weight: 284943.33

Authors

Changela, A.,Gorny, M.K.,Zolla-Pazner, S.,Kwong, P.D. (deposition date: 2010-11-07, release date: 2011-01-05, Last modification date: 2023-09-06)

• Primary citation: Changela, A.,Wu, X.,Yang, Y.,Zhang, B.,Zhu, J.,Nardone, G.A.,O'Dell, S.,Pancera, M.,Gorny, M.K.,Phogat, S.,Robinson, J.E.,Stamatatos, L.,Zolla-Pazner, S.,Mascola, J.R.,Kwong, P.D.; Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Specific Antibodies That Potently Neutralize HIV-1.; J.Virol., 85:2524-2535, 2011; PubMed: 21191009; DOI: 10.1128/JVI.02335-10

Experimental method

X-RAY DIFFRACTION (3.325 Å)