3PHV

X-RAY ANALYSIS OF HIV-1 PROTEINASE AT 2.7 ANGSTROMS RESOLUTION CONFIRMS STRUCTURAL HOMOLOGY AMONG RETROVIRAL ENZYMES

Summary for 3PHV

Entry DOI	10.2210/pdb3phv/pdb
Descriptor	UNLIGANDED HIV-1 PROTEASE (1 entity in total)
Functional Keywords	hydrolase, aspartic proteinase
Biological source	HIV-1 M:B_HXB2R
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
Total number of polymer chains	1
Total formula weight	10803.76
Authors	Lapatto, R.,Blundell, T.L.,Hemmings, A.,Wilderspin, A.,Wood, S.P.,Danley, D.E.,Geoghegan, K.F.,Hawrylik, S.J.,Hobart, P.M. (deposition date: 1991-11-04, release date: 1992-01-15, Last modification date: 2024-02-21)
Primary citation	Lapatto, R.,Blundell, T.,Hemmings, A.,Overington, J.,Wilderspin, A.,Wood, S.,Merson, J.R.,Whittle, P.J.,Danley, D.E.,Geoghegan, K.F.,Hawrylik, S.J.,Lee, S.E.,Scheld, K.G.,Hobart, P.M. X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes. Nature, 342:299-302, 1989 Cited by PubMed: 2682266 DOI: 10.1038/342299a0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation