3PHV

X-RAY ANALYSIS OF HIV-1 PROTEINASE AT 2.7 ANGSTROMS RESOLUTION CONFIRMS STRUCTURAL HOMOLOGY AMONG RETROVIRAL ENZYMES

3PHV の概要

• エントリーDOI: 10.2210/pdb3phv/pdb
• 分子名称: UNLIGANDED HIV-1 PROTEASE (1 entity in total)
• 機能のキーワード: hydrolase, aspartic proteinase
• 由来する生物種: HIV-1 M:B_HXB2R
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10803.76

構造登録者

Lapatto, R.,Blundell, T.L.,Hemmings, A.,Wilderspin, A.,Wood, S.P.,Danley, D.E.,Geoghegan, K.F.,Hawrylik, S.J.,Hobart, P.M. (登録日: 1991-11-04, 公開日: 1992-01-15, 最終更新日: 2024-02-21)

• 主引用文献: Lapatto, R.,Blundell, T.,Hemmings, A.,Overington, J.,Wilderspin, A.,Wood, S.,Merson, J.R.,Whittle, P.J.,Danley, D.E.,Geoghegan, K.F.,Hawrylik, S.J.,Lee, S.E.,Scheld, K.G.,Hobart, P.M.; X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes.; Nature, 342:299-302, 1989; PubMed: 2682266; DOI: 10.1038/342299a0

実験手法

X-RAY DIFFRACTION (2.7 Å)