3PEQ

PPARd complexed with a phenoxyacetic acid partial agonist

Summary for 3PEQ

• Entry DOI: 10.2210/pdb3peq/pdb
• Descriptor: Peroxisome proliferator-activated receptor delta, [(4-{butyl[2-methyl-4'-(methylsulfanyl)biphenyl-3-yl]sulfamoyl}naphthalen-1-yl)oxy]acetic acid, hexyl beta-D-glucopyranoside, ... (5 entities in total)
• Functional Keywords: ppar nuclear receptor, transcription-transcription agonist complex, transcription/transcription agonist
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 64687.89

Authors

Lambert, M.H.,Evans, K.A.,Shearer, B.G.,Wisnoski, D.D.,Shi, D.,Jin, J.,Rivero, R.A.,Sparks, S.M.,Winegar, D.A.,Billin, A.N.,Britt, C.,Way, J.M.,Leesnitzer, L.M.,Merrihew, R.V. (deposition date: 2010-10-27, release date: 2011-10-12, Last modification date: 2023-09-06)

• Primary citation: Evans, K.A.,Shearer, B.G.,Wisnoski, D.D.,Shi, D.,Sparks, S.M.,Sternbach, D.D.,Winegar, D.A.,Billin, A.N.,Britt, C.,Way, J.M.,Epperly, A.H.,Leesnitzer, L.M.,Merrihew, R.V.,Xu, R.X.,Lambert, M.H.,Jin, J.; Phenoxyacetic acid PPARd partial agonists for the treatment of type 2 diabetes: synthesis, optimization, and in vivo efficacy; Bioorg.Med.Chem.Lett., 21:2345-2350, 2011; PubMed: 21414782; DOI: 10.1016/j.bmcl.2011.02.077

Experimental method

X-RAY DIFFRACTION (2.4 Å)