3PEH

Crystal Structure of the N-terminal domain of an HSP90 from Plasmodium Falciparum, PFL1070c in the presence of a thienopyrimidine derivative

Summary for 3PEH

• Entry DOI: 10.2210/pdb3peh/pdb
• Related: 3PEJ
• Descriptor: Endoplasmin homolog, 2-amino-4-{2,4-dichloro-5-[2-(diethylamino)ethoxy]phenyl}-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide, SULFATE ION (3 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, heat shock protein, chaperone, atp binding
• Biological source: Plasmodium falciparum 3D7
• Total number of polymer chains: 2
• Total formula weight: 65287.58

Authors

Wernimont, A.K.,Tempel, W.,Hutchinson, A.,Weadge, J.,Cossar, D.,MacKenzie, F.,Vedadi, M.,Senisterra, G.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Wyatt, P.G.,Fairlamb, A.H.,MacKenzie, C.,Ferguson, M.A.J.,Hui, R.,Pizarro, J.C.,Hills, T.,Structural Genomics Consortium (SGC) (deposition date: 2010-10-26, release date: 2010-11-17, Last modification date: 2023-09-06)

• Primary citation: Wernimont, A.K.,Tempel, W.,Hutchinson, A.,Weadge, J.,Cossar, D.,MacKenzie, F.,Vedadi, M.,Senisterra, G.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Wyatt, P.G.,Fairlamb, A.H.,MacKenzie, C.,Ferguson, M.A.J.,Hui, R.,Pizarro, J.C.,Hills, T.; Crystal Structure of the N-terminal domain of an HSP90 from Plasmodium Falciparum, PFL1070c in the presence of a thienopyrimidine derivative; To be Published,

Experimental method

X-RAY DIFFRACTION (2.75 Å)