3PDN

Crystal structure of SmyD3 in complex with methyltransferase inhibitor sinefungin

3PDN の概要

• エントリーDOI: 10.2210/pdb3pdn/pdb
• 分子名称: SET and MYND domain-containing protein 3, SINEFUNGIN, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: rossmann fold, zinc finger, methyltransferase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q9H7B4
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 50356.91

構造登録者

Sirinupong, N.,Brunzelle, J.,Yang, Z. (登録日: 2010-10-23, 公開日: 2010-11-17, 最終更新日: 2024-02-21)

• 主引用文献: Sirinupong, N.,Brunzelle, J.,Doko, E.,Yang, Z.; Structural Insights into the Autoinhibition and Posttranslational Activation of Histone Methyltransferase SmyD3.; J.Mol.Biol., 406:149-159, 2011; PubMed: 21167177; DOI: 10.1016/j.jmb.2010.12.014

実験手法

X-RAY DIFFRACTION (1.7 Å)