3PDF

Discovery of Novel Cyanamide-Based Inhibitors of Cathepsin C

3PDF の概要

• エントリーDOI: 10.2210/pdb3pdf/pdb
• 分子名称: Dipeptidyl peptidase 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2,5-dibromo-N-{(3R,5S)-1-[(Z)-iminomethyl]-5-methylpyrrolidin-3-yl}benzenesulfonamide, ... (6 entities in total)
• 機能のキーワード: two domains, cystein protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51182.43

構造登録者

Zhao, B.,Laine, D. (登録日: 2010-10-22, 公開日: 2011-10-26, 最終更新日: 2023-07-26)

• 主引用文献: Laine, D.,Palovich, M.,McCleland, B.,Petitjean, E.,Delhom, I.,Xie, H.,Deng, J.,Lin, G.,Davis, R.,Jolit, A.,Nevins, N.,Zhao, B.,Villa, J.,Schneck, J.,McDevitt, P.,Midgett, R.,Kmett, C.,Umbrecht, S.,Peck, B.,Davis, A.B.,Bettoun, D.; Discovery of novel cyanamide-based inhibitors of cathepsin C.; Acs Med.Chem.Lett., 2:142-147, 2011; PubMed: 24900293; DOI: 10.1021/ml100212k

実験手法

X-RAY DIFFRACTION (1.85 Å)