3PBL

Structure of the human dopamine D3 receptor in complex with eticlopride

3PBL の概要

• エントリーDOI: 10.2210/pdb3pbl/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900001
• 分子名称: D(3) dopamine receptor, Lysozyme chimera, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 3-chloro-5-ethyl-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-6-hydroxy-2-methoxybenzamide (3 entities in total)
• 機能のキーワード: structural genomics, psi-2, psi-biology, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d, 7tm, g protein-coupled receptor, gpcr, gpcr network, signal transduction, hydrolase, eticlopride, dopamine, neurotransmitter, chimera, t4l fusion, membrane protein, transmembrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human, Bacteriophage T4); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 108672.38

構造登録者

Chien, E.Y.T.,Liu, W.,Han, G.W.,Katritch, V.,Zhao, Q.,Cherezov, V.,Stevens, R.C.,Accelerated Technologies Center for Gene to 3D Structure (ATCG3D),GPCR Network (GPCR) (登録日: 2010-10-20, 公開日: 2010-11-03, 最終更新日: 2023-09-06)

• 主引用文献: Chien, E.Y.,Liu, W.,Zhao, Q.,Katritch, V.,Han, G.W.,Hanson, M.A.,Shi, L.,Newman, A.H.,Javitch, J.A.,Cherezov, V.,Stevens, R.C.; Structure of the human dopamine d3 receptor in complex with a d2/d3 selective antagonist.; Science, 330:1091-1095, 2010; PubMed: 21097933; DOI: 10.1126/science.1197410

実験手法

X-RAY DIFFRACTION (2.89 Å)