3P9J
Aurora A kinase domain with phthalazinone pyrazole inhibitor
Summary for 3P9J
Entry DOI | 10.2210/pdb3p9j/pdb |
Descriptor | Serine/threonine-protein kinase 6, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1(2H)-one (3 entities in total) |
Functional Keywords | phosphotransferase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 31365.07 |
Authors | Kairies, N.A.,Oliveira, T.,Engh, R.A. (deposition date: 2010-10-17, release date: 2011-03-23, Last modification date: 2024-02-21) |
Primary citation | Prime, M.E.,Courtney, S.M.,Brookfield, F.A.,Marston, R.W.,Walker, V.,Warne, J.,Boyd, A.E.,Kairies, N.A.,von der Saal, W.,Limberg, A.,Georges, G.,Engh, R.A.,Goller, B.,Rueger, P.,Rueth, M. Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of aurora-a kinase. J.Med.Chem., 54:312-319, 2011 Cited by PubMed: 21128645DOI: 10.1021/jm101346r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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