3P8N

Crystal structure of HCV NS3/NS4A protease complexed with BI 201335

3P8N の概要

• エントリーDOI: 10.2210/pdb3p8n/pdb
• 関連するPDBエントリー: 3P8O
• 関連するBIRD辞書のPRD_ID: PRD_000845
• 分子名称: HCV serine protease NS3, HCV non-structural protein 4A, SODIUM ION, ... (5 entities in total)
• 機能のキーワード: hepatitis c virus, ns3, ns4a, halogen bond, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Hepatitis C virus (HCV)
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26662
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 44743.45

構造登録者

Lemke, C.T. (登録日: 2010-10-14, 公開日: 2011-01-26, 最終更新日: 2017-11-08)

• 主引用文献: Lemke, C.T.,Goudreau, N.,Zhao, S.,Hucke, O.,Thibeault, D.,Llinas-Brunet, M.,White, P.W.; Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335.; J.Biol.Chem., 286:11434-11443, 2011; PubMed: 21270126; DOI: 10.1074/jbc.M110.211417

実験手法

X-RAY DIFFRACTION (1.9 Å)