3P8H

Crystal structure of L3MBTL1 (MBT repeat) in complex with a nicotinamide antagonist

3P8H の概要

• エントリーDOI: 10.2210/pdb3p8h/pdb
• 分子名称: Lethal(3)malignant brain tumor-like protein, 3-bromo-5-[(4-pyrrolidin-1-ylpiperidin-1-yl)carbonyl]pyridine, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: lethal(3) malignant brain tumor-like protein, l(3)mbt-like protein, structural genomics consortium, sgc, mbt repeat, transcriptional repression, methylated lysines on histone proteins, transcription
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q9Y468
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 112480.56

構造登録者

Lam, R.,Herold, J.M.,Ouyang, H.,Tempel, W.,Gao, C.,Ravichandran, M.,Senisterra, G.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Vedadi, M.,Kireev, D.,Frye, S.V.,Brown, P.J.,Structural Genomics Consortium (SGC) (登録日: 2010-10-13, 公開日: 2010-11-03, 最終更新日: 2023-09-06)

• 主引用文献: Herold, J.M.,Wigle, T.J.,Norris, J.L.,Lam, R.,Korboukh, V.K.,Gao, C.,Ingerman, L.A.,Kireev, D.B.,Senisterra, G.,Vedadi, M.,Tripathy, A.,Brown, P.J.,Arrowsmith, C.H.,Jin, J.,Janzen, W.P.,Frye, S.V.; Small-molecule ligands of methyl-lysine binding proteins.; J.Med.Chem., 54:2504-2511, 2011; PubMed: 21417280; DOI: 10.1021/jm200045v

実験手法

X-RAY DIFFRACTION (2.55 Å)