3P8F

Crystal Structure of MT-SP1 in complex with SFTI-1

3P8F の概要

• エントリーDOI: 10.2210/pdb3p8f/pdb
• 関連するPDBエントリー: 3P8G
• 関連するBIRD辞書のPRD_ID: PRD_001097
• 分子名称: ST14 protein, Trypsin inhibitor 1, GLUTATHIONE, ... (4 entities in total)
• 機能のキーワード: protein-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28320.94

構造登録者

Yuan, C.,Huang, M.,Chen, L. (登録日: 2010-10-13, 公開日: 2011-08-10, 最終更新日: 2025-03-26)

主引用文献

Yuan, C.,Chen, L.,Meehan, E.J.,Daly, N.,Craik, D.J.,Huang, M.,Ngo, J.C.
Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1.
Bmc Struct.Biol., 11:30-30, 2011

PubMed Abstract: Matriptase is a type II transmembrane serine protease that is found on the surfaces of epithelial cells and certain cancer cells. Matriptase has been implicated in the degradation of certain extracellular matrix components as well as the activation of various cellular proteins and proteases, including hepatocyte growth factor and urokinase. Sunflower trypsin inhibitor-1 (SFTI-1), a cyclic peptide inhibitor originally isolated from sunflower seeds, exhibits potent inhibitory activity toward matriptase.

PubMed: 21693064
DOI: 10.1186/1472-6807-11-30

実験手法

X-RAY DIFFRACTION (2 Å)