3P7L

Rat Insulin Degrading Enzyme (Insulysin)

3P7L の概要

• エントリーDOI: 10.2210/pdb3p7l/pdb
• 関連するPDBエントリー: 3P7O
• 分子名称: Insulin-degrading enzyme, ZINC ION (3 entities in total)
• 機能のキーワード: peptidase, hydrolase
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• 細胞内の位置: Cytoplasm: P35559
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 113374.86

構造登録者

Rodgers, D.W.,Noinaj, N. (登録日: 2010-10-12, 公開日: 2011-07-20, 最終更新日: 2024-02-21)

主引用文献

Noinaj, N.,Bhasin, S.K.,Song, E.S.,Scoggin, K.E.,Juliano, M.A.,Juliano, L.,Hersh, L.B.,Rodgers, D.W.
Identification of the allosteric regulatory site of insulysin.
Plos One, 6:e20864-e20864, 2011

PubMed Abstract: Insulin degrading enzyme (IDE) is responsible for the metabolism of insulin and plays a role in clearance of the Aβ peptide associated with Alzheimer's disease. Unlike most proteolytic enzymes, IDE, which consists of four structurally related domains and exists primarily as a dimer, exhibits allosteric kinetics, being activated by both small substrate peptides and polyphosphates such as ATP.

PubMed: 21731629
DOI: 10.1371/journal.pone.0020864

実験手法

X-RAY DIFFRACTION (2.0776 Å)