3P76
X-ray crystal structure of Aquifex aeolicus LpxC complexed SCH1379777
Summary for 3P76
Entry DOI | 10.2210/pdb3p76/pdb |
Descriptor | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, IMIDAZOLE, N-[(1S,2R)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-[4-(phenylethynyl)phenyl]piperidine-1-carboxamide, ... (5 entities in total) |
Functional Keywords | amidohydrolases, amino acid motifs, binding sites, drug design, enzyme inhibitors, escherichia coli proteins, hydrophobicity, lipid a, protein conformation, protein folding, recombinant fusion proteins, structure-activity relationship, hydrolase |
Biological source | Aquifex aeolicus |
Total number of polymer chains | 1 |
Total formula weight | 31610.90 |
Authors | Orth, P. (deposition date: 2010-10-12, release date: 2011-02-09, Last modification date: 2023-09-06) |
Primary citation | Faruk Mansoor, U.,Vitharana, D.,Reddy, P.A.,Daubaras, D.L.,McNicholas, P.,Orth, P.,Black, T.,Arshad Siddiqui, M. Design and synthesis of potent Gram-negative specific LpxC inhibitors. Bioorg.Med.Chem.Lett., 21:1155-1161, 2011 Cited by PubMed: 21273067DOI: 10.1016/j.bmcl.2010.12.111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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