3P76
X-ray crystal structure of Aquifex aeolicus LpxC complexed SCH1379777
3P76 の概要
エントリーDOI | 10.2210/pdb3p76/pdb |
分子名称 | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, IMIDAZOLE, N-[(1S,2R)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-[4-(phenylethynyl)phenyl]piperidine-1-carboxamide, ... (5 entities in total) |
機能のキーワード | amidohydrolases, amino acid motifs, binding sites, drug design, enzyme inhibitors, escherichia coli proteins, hydrophobicity, lipid a, protein conformation, protein folding, recombinant fusion proteins, structure-activity relationship, hydrolase |
由来する生物種 | Aquifex aeolicus |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 31610.90 |
構造登録者 | |
主引用文献 | Faruk Mansoor, U.,Vitharana, D.,Reddy, P.A.,Daubaras, D.L.,McNicholas, P.,Orth, P.,Black, T.,Arshad Siddiqui, M. Design and synthesis of potent Gram-negative specific LpxC inhibitors. Bioorg.Med.Chem.Lett., 21:1155-1161, 2011 Cited by PubMed: 21273067DOI: 10.1016/j.bmcl.2010.12.111 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.93 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード