3P5S

Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally flexible covalent enzyme-substrate complex

3P5S の概要

• エントリーDOI: 10.2210/pdb3p5s/pdb
• 関連するPDBエントリー: 3GC6 3GH3 3GHH 3KOU
• 分子名称: CD38 molecule, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: cd38, cyclic adp ribose, ecto-adp-ribosyl cyclase, glycosidase, hydrolase
• 由来する生物種: Bos taurus (bovine,cow,domestic cattle,domestic cow)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64899.41

構造登録者

Egea, P.F.,Muller-Stauffler, H.,Kohn, I.,Cakou-Kefir, C.,Stroud, R.M.,Kellenberburger, E.,Schuber, F. (登録日: 2010-10-10, 公開日: 2011-10-19, 最終更新日: 2023-09-06)

• 主引用文献: Egea, P.F.,Muller-Steffner, H.,Kuhn, I.,Cakir-Kiefer, C.,Oppenheimer, N.J.,Stroud, R.M.,Kellenberger, E.,Schuber, F.; Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates.; Plos One, 7:e34918-e34918, 2012; PubMed: 22529956; DOI: 10.1371/journal.pone.0034918

実験手法

X-RAY DIFFRACTION (1.95 Å)