3P5O

Crystal Structure of the First Bromodomain of Human Brd4 in complex with IBET inhibitor

3P5O の概要

• エントリーDOI: 10.2210/pdb3p5o/pdb
• 分子名称: Bromodomain-containing protein 4, 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: brd4, bromodomain containing protein 4, antagonist, ibet, inhibition of acetylated lysine histone binding, transcription regulator, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus (By similarity): O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15771.55

構造登録者

Chung, C. (登録日: 2010-10-09, 公開日: 2010-11-17, 最終更新日: 2023-11-01)

• 主引用文献: Nicodeme, E.,Jeffrey, K.L.,Schaefer, U.,Beinke, S.,Dewell, S.,Chung, C.,Chandwani, R.,Marazzi, I.,Wilson, P.,Coste, H.,White, J.,Kirilovsky, J.,Rice, C.M.,Lora, J.M.,Prinjha, R.K.,Lee, K.,Tarakhovsky, A.; Suppression of inflammation by a synthetic histone mimic; Nature, 468:1119-1123, 2010; PubMed: 21068722; DOI: 10.1038/nature09589

実験手法

X-RAY DIFFRACTION (1.6 Å)