3OZG

Crystal Structure of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase in complex with S-SerMe-ImmH phosphonate

Summary for 3OZG

• Entry DOI: 10.2210/pdb3ozg/pdb
• Related: 3OZF
• Descriptor: Hypoxanthine-guanine-xanthine phosphoribosyltransferase, [(3S)-4-hydroxy-3-{[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino}butyl]phosphonic acid, PYROPHOSPHATE 2-, ... (5 entities in total)
• Functional Keywords: hypoxanthine, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Plasmodium falciparum FCR-3/Gambia
• Cellular location: Cytoplasm: P20035
• Total number of polymer chains: 4
• Total formula weight: 115708.84

Authors

Ho, M.,Hazleton, K.Z.,Almo, S.C.,Schramm, V.L. (deposition date: 2010-09-24, release date: 2011-09-28, Last modification date: 2023-09-06)

• Primary citation: Hazleton, K.Z.,Ho, M.C.,Cassera, M.B.,Clinch, K.,Crump, D.R.,Rosario, I.,Merino, E.F.,Almo, S.C.,Tyler, P.C.,Schramm, V.L.; Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase.; Chem.Biol., 19:721-730, 2012; PubMed: 22726686; DOI: 10.1016/j.chembiol.2012.04.012

Experimental method

X-RAY DIFFRACTION (1.993 Å)