3OZ4
R-Methyl Carbocyclic LNA
Summary for 3OZ4
Entry DOI | 10.2210/pdb3oz4/pdb |
Related | 3OZ3 3OZ5 |
Descriptor | DNA (5'-D(*GP*CP*GP*TP*AP*(URX)P*AP*CP*GP*C)-3') (2 entities in total) |
Functional Keywords | a-form dna, r-methyl carbocyclic lna, r-me-c-lna, antisense oligonucleotides, dna |
Total number of polymer chains | 2 |
Total formula weight | 6142.09 |
Authors | Seth, P.R.,Allerson, C.A.,Berdeja, A.,Siwkowski, A.,Pallan, P.S.,Gaus, H.,Prakash, T.P.,Watt, A.T.,Egli, M.,Swayze, E.E. (deposition date: 2010-09-24, release date: 2010-11-24, Last modification date: 2023-09-06) |
Primary citation | Seth, P.P.,Allerson, C.R.,Berdeja, A.,Siwkowski, A.,Pallan, P.S.,Gaus, H.,Prakash, T.P.,Watt, A.T.,Egli, M.,Swayze, E.E. An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA. J.Am.Chem.Soc., 132:14942-14950, 2010 Cited by PubMed: 20886816DOI: 10.1021/ja105875e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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