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3OXZ

Crystal structure of ABL kinase domain bound with a DFG-out inhibitor AP24534

Summary for 3OXZ
Entry DOI10.2210/pdb3oxz/pdb
Related3IK3 3OY3
DescriptorTyrosine-protein kinase ABL1, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide (3 entities in total)
Functional Keywordsprotein-inhibitor complex, protein kinase two-domain fold, phosphotransferase, atp binding, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceMus musculus (mouse)
Cellular locationCytoplasm, cytoskeleton: P00520
Total number of polymer chains1
Total formula weight33330.00
Authors
Zhou, T.,Huang, W.S.,Wang, Y.,Thomas, M.,Keats, J.,Xu, Q.,Rivera, V.,Shakespeare, W.C.,Clackson, T.,Dalgarno, D.C.,Zhu, X. (deposition date: 2010-09-22, release date: 2010-12-15, Last modification date: 2023-09-06)
Primary citationZhou, T.,Commodore, L.,Huang, W.S.,Wang, Y.,Thomas, M.,Keats, J.,Xu, Q.,Rivera, V.M.,Shakespeare, W.C.,Clackson, T.,Dalgarno, D.C.,Zhu, X.
Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance.
Chem.Biol.Drug Des., 77:1-11, 2011
Cited by
PubMed: 21118377
DOI: 10.1111/j.1747-0285.2010.01054.x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

217705

數據於2024-03-27公開中

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