3OWN
Potent macrocyclic renin inhibitors
Summary for 3OWN
Entry DOI | 10.2210/pdb3own/pdb |
Descriptor | Renin, ACETATE ION, SODIUM ION, ... (6 entities in total) |
Functional Keywords | renin, protease, aspartyl protease, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P00797 |
Total number of polymer chains | 2 |
Total formula weight | 76419.15 |
Authors | Borkakoti, N.,Derbyshire, D. (deposition date: 2010-09-20, release date: 2010-12-15, Last modification date: 2011-07-13) |
Primary citation | Sund, C.,Belda, O.,Wiktelius, D.,Sahlberg, C.,Vrang, L.,Sedig, S.,Hamelink, E.,Henderson, I.,Agback, T.,Jansson, K.,Borkakoti, N.,Derbyshire, D.,Eneroth, A.,Samuelsson, B. Design and synthesis of potent macrocyclic renin inhibitors. Bioorg.Med.Chem.Lett., 21:358-362, 2011 Cited by PubMed: 21112780DOI: 10.1016/j.bmcl.2010.10.140 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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