3OWL

Human CK2 catalytic domain in complex with a benzopyridoindole derivative inhibitor

3OWL の概要

• エントリーDOI: 10.2210/pdb3owl/pdb
• 関連するPDBエントリー: 3MB6 3MB7 3OWJ 3OWK
• 分子名称: CSNK2A1 protein, 11-chloro-8-methyl-7H-benzo[e]pyrido[4,3-b]indol-3-ol, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: serine/threonine-protein kinase, ck2, inhibitor, pyridocarbazol, ellipticine, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40221.14

構造登録者

Reiser, J.-B.,Prudent, R.,Cochet, C. (登録日: 2010-09-20, 公開日: 2010-12-15, 最終更新日: 2024-02-21)

• 主引用文献: Prudent, R.,Moucadel, V.,Nguyen, C.H.,Barette, C.,Schmidt, F.,Florent, J.C.,Lafanechere, L.,Sautel, C.F.,Duchemin-Pelletier, E.,Spreux, E.,Filhol, O.,Reiser, J.B.,Cochet, C.; Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2.; Cancer Res., 70:9865-9874, 2010; PubMed: 21118972; DOI: 10.1158/0008-5472.CAN-10-0917

実験手法

X-RAY DIFFRACTION (2.1 Å)