3OWJ
Human CK2 catalytic domain in complex with a pyridocarbazole derivative inhibitor
Summary for 3OWJ
Entry DOI | 10.2210/pdb3owj/pdb |
Related | 3MB6 3MB7 3OWK 3OWL |
Descriptor | CSNK2A1 protein, 9-hydroxy-5,11-dimethyl-4,6-dihydro-1H-pyrido[4,3-b]carbazol-1-one (3 entities in total) |
Functional Keywords | serine/threonine-protein kinase, ck2, inhibitor, pyridocarbazole, ellipticine, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 39928.53 |
Authors | Reiser, J.-B.,Prudent, R.,Cochet, C. (deposition date: 2010-09-20, release date: 2010-12-15, Last modification date: 2024-02-21) |
Primary citation | Prudent, R.,Moucadel, V.,Nguyen, C.H.,Barette, C.,Schmidt, F.,Florent, J.C.,Lafanechere, L.,Sautel, C.F.,Duchemin-Pelletier, E.,Spreux, E.,Filhol, O.,Reiser, J.B.,Cochet, C. Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2. Cancer Res., 70:9865-9874, 2010 Cited by PubMed: 21118972DOI: 10.1158/0008-5472.CAN-10-0917 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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