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3OW6

Crystal Structure of HSP90 with N-Aryl-benzimidazolone I

Summary for 3OW6
Entry DOI10.2210/pdb3ow6/pdb
Related3OWB 3OWD
DescriptorHeat shock protein HSP 90-alpha, 1-(2,4-dihydroxyphenyl)-1,3-dihydro-2H-benzimidazol-2-one (3 entities in total)
Functional Keywordshsp90, chaperone
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P07900
Total number of polymer chains1
Total formula weight23390.48
Authors
Park, C.H. (deposition date: 2010-09-17, release date: 2011-09-21, Last modification date: 2024-02-21)
Primary citationBruncko, M.,Tahir, S.K.,Song, X.,Chen, J.,Ding, H.,Huth, J.R.,Jin, S.,Judge, R.A.,Madar, D.J.,Park, C.H.,Park, C.M.,Petros, A.M.,Tse, C.,Rosenberg, S.H.,Elmore, S.W.
N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Bioorg.Med.Chem.Lett., 20:7503-7506, 2010
Cited by
PubMed: 21106457
DOI: 10.1016/j.bmcl.2010.10.010
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

217705

數據於2024-03-27公開中

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