3OW3
Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors
Summary for 3OW3
Entry DOI | 10.2210/pdb3ow3/pdb |
Related | 3OW4 |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, (2R)-3-(1H-indol-3-yl)-1-{4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}-1-oxopropan-2-amine, ... (4 entities in total) |
Functional Keywords | cyclic-amp dependent protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mus musculus (mouse) More |
Cellular location | Cytoplasm: P05132 |
Total number of polymer chains | 2 |
Total formula weight | 43306.27 |
Authors | Dizon, F.,Wu, W.,Vigers, G.P.A.,Brandhuber, B.J. (deposition date: 2010-09-17, release date: 2010-11-10, Last modification date: 2023-09-06) |
Primary citation | Bencsik, J.R.,Xiao, D.,Blake, J.F.,Kallan, N.C.,Mitchell, I.S.,Spencer, K.L.,Xu, R.,Gloor, S.L.,Martinson, M.,Risom, T.,Woessner, R.D.,Dizon, F.,Wu, W.I.,Vigers, G.P.,Brandhuber, B.J.,Skelton, N.J.,Prior, W.W.,Murray, L.J. Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors. Bioorg.Med.Chem.Lett., 20:7037-7041, 2010 Cited by PubMed: 20971641DOI: 10.1016/j.bmcl.2010.09.112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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