3OW3

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

3OW3 の概要

• エントリーDOI: 10.2210/pdb3ow3/pdb
• 関連するPDBエントリー: 3OW4
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, (2R)-3-(1H-indol-3-yl)-1-{4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}-1-oxopropan-2-amine, ... (4 entities in total)
• 機能のキーワード: cyclic-amp dependent protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mus musculus (mouse); 詳細
• 細胞内の位置: Cytoplasm: P05132
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43306.27

構造登録者

Dizon, F.,Wu, W.,Vigers, G.P.A.,Brandhuber, B.J. (登録日: 2010-09-17, 公開日: 2010-11-10, 最終更新日: 2023-09-06)

• 主引用文献: Bencsik, J.R.,Xiao, D.,Blake, J.F.,Kallan, N.C.,Mitchell, I.S.,Spencer, K.L.,Xu, R.,Gloor, S.L.,Martinson, M.,Risom, T.,Woessner, R.D.,Dizon, F.,Wu, W.I.,Vigers, G.P.,Brandhuber, B.J.,Skelton, N.J.,Prior, W.W.,Murray, L.J.; Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors.; Bioorg.Med.Chem.Lett., 20:7037-7041, 2010; PubMed: 20971641; DOI: 10.1016/j.bmcl.2010.09.112

実験手法

X-RAY DIFFRACTION (1.9 Å)