3OTH

Crystal Structure of CalG1, Calicheamicin Glycostyltransferase, TDP and calicheamicin alpha3I bound form

3OTH の概要

• エントリーDOI: 10.2210/pdb3oth/pdb
• 関連するPDBエントリー: 3D0Q 3D0R 3OTG 3OTI
• 分子名称: CalG1, THYMIDINE-5'-DIPHOSPHATE, Calicheamicin alpha3I, ... (4 entities in total)
• 機能のキーワード: calicheamicin, tdp, structural genomics, psi-2, protein structure initiative, center for eukaryotic structural genomics, cesg, gt-b fold, glycosyltransferase, transferase-antibiotic complex, enzyme discovery for natural product biosynthesis, natpro, transferase/antibiotic
• 由来する生物種: Micromonospora echinospora (Micromonospora purpurea)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 90696.07

構造登録者

Chang, A.,Singh, S.,Bingman, C.A.,Thorson, J.S.,Phillips Jr., G.N.,Center for Eukaryotic Structural Genomics (CESG),Enzyme Discovery for Natural Product Biosynthesis (NatPro) (登録日: 2010-09-11, 公開日: 2010-12-15, 最終更新日: 2017-11-08)

• 主引用文献: Chang, A.,Singh, S.,Helmich, K.E.,Goff, R.D.,Bingman, C.A.,Thorson, J.S.,Phillips, G.N.; Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.; Proc.Natl.Acad.Sci.USA, 108:17649-17654, 2011; PubMed: 21987796; DOI: 10.1073/pnas.1108484108

実験手法

X-RAY DIFFRACTION (2.301 Å)