3OPM

Crystal Structure of Human DPP4 Bound to TAK-294

3OPM の概要

• エントリーDOI: 10.2210/pdb3opm/pdb
• 関連するPDBエントリー: 3O95 3O9V
• 分子名称: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-6-yl]oxy}acetamide, ... (5 entities in total)
• 機能のキーワード: protease and 8-bladed beta-propeller domain, aminopeptidase, cell membrane, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane, signaling protein, hydrolase-hydrolase inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 348364.11

構造登録者

Yano, J.K.,Aertgeerts, K. (登録日: 2010-09-01, 公開日: 2011-10-19, 最終更新日: 2020-07-29)

• 主引用文献: Banno, Y.,Miyamoto, Y.,Sasaki, M.,Oi, S.,Asakawa, T.,Kataoka, O.,Takeuchi, K.,Suzuki, N.,Ikedo, K.,Kosaka, T.,Tsubotani, S.,Tani, A.,Funami, M.,Tawada, M.,Yamamoto, Y.,Aertgeerts, K.,Yano, J.,Maezaki, H.; Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: a new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554.; Bioorg.Med.Chem., 19:4953-4970, 2011; PubMed: 21764322; DOI: 10.1016/j.bmc.2011.06.059

実験手法

X-RAY DIFFRACTION (2.72 Å)