3OP8

Crystal structure of the domain V from beta2-glycoprotein I

3OP8 の概要

• エントリーDOI: 10.2210/pdb3op8/pdb
• 関連するPDBエントリー: 1C1Z 1QUB
• 分子名称: Beta-2-glycoprotein 1, SULFATE ION (3 entities in total)
• 機能のキーワード: sushi, antiphospholipid syndrome, anionic phospholipids binding, lipoprotein receptors binding, blood plasma, protein binding
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02749
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 19548.51

構造登録者

Kolyada, A.,Lee, C.-J.,De Biasio, A.,Beglova, N. (登録日: 2010-08-31, 公開日: 2011-01-05, 最終更新日: 2011-07-13)

主引用文献

Kolyada, A.,Lee, C.J.,De Biasio, A.,Beglova, N.
A Novel Dimeric Inhibitor Targeting Beta2GPI in Beta2GPI/Antibody Complexes Implicated in Antiphospholipid Syndrome.
Plos One, 5:e15345-e15345, 2010

PubMed Abstract: β2GPI is a major antigen for autoantibodies associated with antiphospholipid syndrome (APS), an autoimmune disease characterized by thrombosis and recurrent pregnancy loss. Only the dimeric form of β2GPI generated by anti-β2GPI antibodies is pathologically important, in contrast to monomeric β2GPI which is abundant in plasma.

PubMed: 21179511
DOI: 10.1371/journal.pone.0015345

実験手法

X-RAY DIFFRACTION (1.9 Å)