3OOM

Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507

3OOM の概要

• エントリーDOI: 10.2210/pdb3oom/pdb
• 関連するPDBエントリー: 3MTF
• 分子名称: Activin receptor type-1, PHOSPHATE ION, 1-{3-[6-(tetrahydro-2H-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone, ... (5 entities in total)
• 機能のキーワード: protein kinase, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: Q04771
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35994.98

構造登録者

Chaikuad, A.,Sanvitale, C.,Cooper, C.,Mahajan, P.,Daga, N.,Petrie, K.,Alfano, I.,Gileadi, O.,Fedorov, O.,Allerston, C.,Krojer, T.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (登録日: 2010-08-31, 公開日: 2010-10-13, 最終更新日: 2023-11-01)

• 主引用文献: Chaikuad, A.,Sanvitale, C.,Cooper, C.,Mahajan, P.,Daga, N.,Petrie, K.,Alfano, I.,Gileadi, O.,Fedorov, O.,Allerston, C.,Krojer, T.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.; Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507; To be Published,

実験手法

X-RAY DIFFRACTION (2 Å)