3ONR

Crystal structure of the calcium chelating immunodominant antigen, calcium dodecin (Rv0379),from Mycobacterium tuberculosis with a novel calcium-binding site

Summary for 3ONR

• Entry DOI: 10.2210/pdb3onr/pdb
• Descriptor: PROTEIN TRANSPORT PROTEIN SECE2, CALCIUM ION, FORMIC ACID, ... (5 entities in total)
• Functional Keywords: calcium dodecin, calcium binding protein, dodecamer, imuuno dominant antigen, metal binding protein
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 12
• Total formula weight: 97876.65

Authors

Arulandu, A.,Sacchettini, J.C. (deposition date: 2010-08-30, release date: 2011-03-16, Last modification date: 2024-02-21)

Primary citation

Arockiasamy, A.,Aggarwal, A.,Savva, C.G.,Holzenburg, A.,Sacchettini, J.C.
Crystal structure of calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium-binding site.
Protein Sci., 20:827-833, 2011

PubMed Abstract: In eukaryotes, calcium-binding proteins play a pivotal role in diverse cellular processes, and recent findings suggest similar roles for bacterial proteins at different stages in their life cycle. Here, we report the crystal structure of calcium dodecin, Rv0379, from Mycobacterium tuberculosis with a dodecameric oligomeric assembly and a unique calcium-binding motif. Structure and sequence analysis were used to identify orthologs of Rv0379 with different ligand-binding specificity.

PubMed: 21370306
DOI: 10.1002/pro.607

Experimental method

X-RAY DIFFRACTION (1.8 Å)