3ONR

Crystal structure of the calcium chelating immunodominant antigen, calcium dodecin (Rv0379),from Mycobacterium tuberculosis with a novel calcium-binding site

3ONR の概要

• エントリーDOI: 10.2210/pdb3onr/pdb
• 分子名称: PROTEIN TRANSPORT PROTEIN SECE2, CALCIUM ION, FORMIC ACID, ... (5 entities in total)
• 機能のキーワード: calcium dodecin, calcium binding protein, dodecamer, imuuno dominant antigen, metal binding protein
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 97876.65

構造登録者

Arulandu, A.,Sacchettini, J.C. (登録日: 2010-08-30, 公開日: 2011-03-16, 最終更新日: 2024-02-21)

主引用文献

Arockiasamy, A.,Aggarwal, A.,Savva, C.G.,Holzenburg, A.,Sacchettini, J.C.
Crystal structure of calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium-binding site.
Protein Sci., 20:827-833, 2011

PubMed Abstract: In eukaryotes, calcium-binding proteins play a pivotal role in diverse cellular processes, and recent findings suggest similar roles for bacterial proteins at different stages in their life cycle. Here, we report the crystal structure of calcium dodecin, Rv0379, from Mycobacterium tuberculosis with a dodecameric oligomeric assembly and a unique calcium-binding motif. Structure and sequence analysis were used to identify orthologs of Rv0379 with different ligand-binding specificity.

PubMed: 21370306
DOI: 10.1002/pro.607

実験手法

X-RAY DIFFRACTION (1.8 Å)