3OMU

Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a thienopyrimidine derivative

Summary for 3OMU

Entry DOI	10.2210/pdb3omu/pdb
Related	3O6O
Descriptor	Heat shock protein 83, 2-amino-4-{2,4-dichloro-5-[2-(diethylamino)ethoxy]phenyl}-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide (3 entities in total)
Functional Keywords	hsp90, trypanosoma bruceii, structural genomics, drug discovery, structural genomics consortium, sgc, chaperone
Biological source	Trypanosoma brucei
Total number of polymer chains	2
Total formula weight	53365.62
Authors	Wernimont, A.K.,Hutchinson, A.,Sullivan, H.,Weadge, J.,Cossar, D.,Li, Y.,Kozieradzki, I.,Bochkarev, A.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Wyatt, P.G.,Fairlamb, A.H.,MacKenzie, C.,Ferguson, M.A.J.,Hui, R.,Pizarro, J.C.,Hills, T.,Structural Genomics Consortium (SGC) (deposition date: 2010-08-27, release date: 2010-10-27, Last modification date: 2023-09-06)
Primary citation	Pizarro, J.C.,Hills, T.,Senisterra, G.,Wernimont, A.K.,Mackenzie, C.,Norcross, N.R.,Ferguson, M.A.,Wyatt, P.G.,Gilbert, I.H.,Hui, R. Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design. PLoS Negl Trop Dis, 7:e2492-e2492, 2013 Cited by PubMed: 24147171 DOI: 10.1371/journal.pntd.0002492 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation