3OMU

Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a thienopyrimidine derivative

3OMU の概要

• エントリーDOI: 10.2210/pdb3omu/pdb
• 関連するPDBエントリー: 3O6O
• 分子名称: Heat shock protein 83, 2-amino-4-{2,4-dichloro-5-[2-(diethylamino)ethoxy]phenyl}-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide (3 entities in total)
• 機能のキーワード: hsp90, trypanosoma bruceii, structural genomics, drug discovery, structural genomics consortium, sgc, chaperone
• 由来する生物種: Trypanosoma brucei
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53365.62

構造登録者

Wernimont, A.K.,Hutchinson, A.,Sullivan, H.,Weadge, J.,Cossar, D.,Li, Y.,Kozieradzki, I.,Bochkarev, A.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Wyatt, P.G.,Fairlamb, A.H.,MacKenzie, C.,Ferguson, M.A.J.,Hui, R.,Pizarro, J.C.,Hills, T.,Structural Genomics Consortium (SGC) (登録日: 2010-08-27, 公開日: 2010-10-27, 最終更新日: 2023-09-06)

• 主引用文献: Pizarro, J.C.,Hills, T.,Senisterra, G.,Wernimont, A.K.,Mackenzie, C.,Norcross, N.R.,Ferguson, M.A.,Wyatt, P.G.,Gilbert, I.H.,Hui, R.; Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design.; PLoS Negl Trop Dis, 7:e2492-e2492, 2013; PubMed: 24147171; DOI: 10.1371/journal.pntd.0002492

実験手法

X-RAY DIFFRACTION (2.15 Å)