3OKU

Human Carbonic Anhydrase II in complex with 2-Ethylestrone-3-O-sulfamate

3OKU の概要

関連するPDBエントリー3IOK 3IOL 3IOM 3OKV
分子名称Carbonic anhydrase 2, ZINC ION, (9beta)-2-ethyl-17-oxoestra-1(10),2,4-trien-3-yl sulfamate, ... (6 entities in total)
機能のキーワードmixed alpha/beta fold, reversible hydration of carbon dioxide to bicarbonate, lyase
由来する生物種Homo sapiens (human)
細胞内の位置Cytoplasm  P00918
ポリマー鎖数1
分子量合計29902.2
構造登録者
Sippel, K.H.,Stander, B.A.,Robbins, A.H.,Tu, C.K.,Agbandje-McKenna, M.,Silverman, D.N.,Joubert, A.M.,McKenna, R. (登録日: 2010-08-25, 公開日: 2011-07-06, 最終更新日: 2017-11-08)
主引用文献
Sippel, K.H.,Stander, B.A.,Robbins, A.H.,Tu, C.K.,Agbandje-McKenna, M.,Silverman, D.N.,Joubert, A.M.,McKenna, R.
Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds
LETT.DRUG DES.DISCOVERY, 8:-, 2011
実験手法
X-RAY DIFFRACTION (1.45 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.1579003.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード