3OKJ

Alpha-keto-aldehyde binding mechanism reveals a novel lead structure motif for proteasome inhibition

Summary for 3OKJ

• Entry DOI: 10.2210/pdb3okj/pdb
• Related: 1G65 1J2Q 1RYP 3D29
• Related PRD ID: PRD_001051
• Descriptor: Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
• Functional Keywords: ubiquitin, protease, inhibitor, central antiparallel beta-sheet flanked by helices, turnover of ubiquitinated substrates, nucleus, cytosol, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae (yeast); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 28
• Total formula weight: 705317.56

Authors

Groll, M.,Poynor, M.,Gallastegui, P.,Stein, M.,Schmidt, B.,Kloetzel, P.M.,Huber, R. (deposition date: 2010-08-25, release date: 2011-06-08, Last modification date: 2023-09-06)

• Primary citation: Grawert, M.A.,Gallastegui, N.,Stein, M.,Schmidt, B.,Kloetzel, P.M.,Huber, R.,Groll, M.; Elucidation of the alpha-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibition; Angew.Chem.Int.Ed.Engl., 50:542-544, 2011; PubMed: 21154547; DOI: 10.1002/anie.201005488

Experimental method

X-RAY DIFFRACTION (2.7 Å)