3OJ7

Crystal structure of a histidine triad family protein from entamoeba histolytica, bound to sulfate

3OJ7 の概要

• エントリーDOI: 10.2210/pdb3oj7/pdb
• 関連するPDBエントリー: 3OMF 3OXK
• 分子名称: Putative histidine triad family protein, ZINC ION, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hydrolase, structural genomics, seattle structural genomics center for infectious disease, ssgcid, metal binding protein
• 由来する生物種: Entamoeba histolytica
• 細胞内の位置: Nucleus : C4LYI2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13178.56

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2010-08-20, 公開日: 2010-09-08, 最終更新日: 2023-09-06)

主引用文献

Lorimer, D.D.,Choi, R.,Abramov, A.,Nakazawa Hewitt, S.,Gardberg, A.S.,Van Voorhis, W.C.,Staker, B.L.,Myler, P.J.,Edwards, T.E.
Structures of a histidine triad family protein from Entamoeba histolytica bound to sulfate, AMP and GMP.
Acta Crystallogr F Struct Biol Commun, 71:572-576, 2015

PubMed Abstract: Three structures of the histidine triad family protein from Entamoeba histolytica, the causative agent of amoebic dysentery, were solved at high resolution within the Seattle Structural Genomics Center for Infectious Disease (SSGCID). The structures have sulfate (PDB entry 3oj7), AMP (PDB entry 3omf) or GMP (PDB entry 3oxk) bound in the active site, with sulfate occupying the same space as the α-phosphate of the two nucleotides. The C(α) backbones of the three structures are nearly superimposable, with pairwise r.m.s.d.s ranging from 0.06 to 0.13 Å.

PubMed: 25945711
DOI: 10.1107/S2053230X1500237X

実験手法

X-RAY DIFFRACTION (1.4 Å)