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3OIX

Crystal structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans

3OIX の概要
エントリーDOI10.2210/pdb3oix/pdb
分子名称Putative dihydroorotate dehydrogenase; dihydroorotate oxidase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... (4 entities in total)
機能のキーワードtim barrel, oxidoreductase
由来する生物種Streptococcus mutans
細胞内の位置Cytoplasm : Q8DVA1
タンパク質・核酸の鎖数4
化学式量合計154074.78
構造登録者
Liu, Y.,Gao, Z.Q.,Liu, C.P.,Dong, Y.H. (登録日: 2010-08-20, 公開日: 2010-09-08, 最終更新日: 2023-11-01)
主引用文献Liu, Y.,Gao, Z.-Q.,Liu, C.-P.,Xu, J.-H.,Li, L.-F.,Ji, C.-N.,Su, X.-D.,Dong, Y.-H.
Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans
Acta Crystallogr.,Sect.F, 67:182-187, 2011
Cited by
PubMed Abstract: Streptococcus mutans is one of the pathogenic species involved in dental caries, especially in the initiation and development stages. Here, the crystal structure of SMU.595, a putative dihydroorotate dehydrogenase (DHOD) from S. mutans, is reported at 2.4 Å resolution. DHOD is a flavin mononucleotide-containing enzyme which catalyzes the oxidation of L-dihydroorotate to orotate, which is the fourth step and the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. The reductive lysine-methylation procedure was applied in order to improve the diffraction qualities of the crystals. Analysis of the S. mutans DHOD crystal structure shows that this enzyme is a class 1A DHOD and also suggests potential sites that could be exploited for the design of highly specific inhibitors using the structure-based chemotherapeutic design technique.
PubMed: 21301083
DOI: 10.1107/S1744309110048414
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.399 Å)
構造検証レポート
Validation report summary of 3oix
検証レポート(詳細版)ダウンロードをダウンロード

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件を2025-07-30に公開中

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