3OHX

Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b

Replaces:  3NSA

Summary for 3OHX

• Entry DOI: 10.2210/pdb3ohx/pdb
• Related: 3L3O 3NMS
• Descriptor: Complement C3, Staphylococcal complement inhibitor, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: complement component c3, complement alternate pathway, complement pathway, convertase, immune evasion, innate immunity, secreted virulence factor, immune system
• Biological source: Staphylococcus aureus; More
• Cellular location: Secreted: P01024 P01024 P01024 Q931M7
• Total number of polymer chains: 8
• Total formula weight: 289675.12

Authors

Geisbrecht, B.V.,Garcia, B.L. (deposition date: 2010-08-18, release date: 2010-09-01, Last modification date: 2020-07-29)

• Primary citation: Garcia, B.L.,Ramyar, K.X.,Tzekou, A.,Ricklin, D.,McWhorter, W.J.,Lambris, J.D.,Geisbrecht, B.V.; Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.; J.Mol.Biol., 402:17-29, 2010; PubMed: 20654625; DOI: 10.1016/j.jmb.2010.07.029

Experimental method

X-RAY DIFFRACTION (3.503 Å)