3OGJ

Crystal structure of partial apo (92-227) of cGMP-dependent protein kinase

3OGJ の概要

• エントリーDOI: 10.2210/pdb3ogj/pdb
• 関連するPDBエントリー: 3OCP 3OD0
• 分子名称: PRKG1 protein, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: serine/threonine kinase, tf2i and irag, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 63277.07

構造登録者

Kim, J.J.,Huang, G.,Kwon, T.K.,Zwart, P.,Headd, J.,Kim, C. (登録日: 2010-08-16, 公開日: 2011-05-11, 最終更新日: 2024-02-21)

主引用文献

Kim, J.J.,Casteel, D.E.,Huang, G.,Kwon, T.H.,Ren, R.K.,Zwart, P.,Headd, J.J.,Brown, N.G.,Chow, D.C.,Palzkill, T.,Kim, C.
Co-Crystal Structures of PKG Ibeta (92-227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding
Plos One, 6:e18413-e18413, 2011

PubMed Abstract: Cyclic GMP-dependent protein kinases (PKGs) are central mediators of the NO-cGMP signaling pathway and phosphorylate downstream substrates that are crucial for regulating smooth muscle tone, platelet activation, nociception and memory formation. As one of the main receptors for cGMP, PKGs mediate most of the effects of cGMP elevating drugs, such as nitric oxide-releasing agents and phosphodiesterase inhibitors which are used for the treatment of angina pectoris and erectile dysfunction, respectively.

PubMed: 21526164
DOI: 10.1371/journal.pone.0018413

実験手法

X-RAY DIFFRACTION (2.751 Å)