3OG7

B-Raf Kinase V600E oncogenic mutant in complex with PLX4032

Summary for 3OG7

• Entry DOI: 10.2210/pdb3og7/pdb
• Descriptor: AKAP9-BRAF fusion protein, N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide (3 entities in total)
• Functional Keywords: b-raf, braf, proto-oncogene, v600e, kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 66445.41

Authors

Zhang, Y.,Zhang, K.Y.,Zhang, C. (deposition date: 2010-08-16, release date: 2010-09-22, Last modification date: 2024-02-21)

• Primary citation: Bollag, G.,Hirth, P.,Tsai, J.,Zhang, J.,Ibrahim, P.N.,Cho, H.,Spevak, W.,Zhang, C.,Zhang, Y.,Habets, G.,Burton, E.A.,Wong, B.,Tsang, G.,West, B.L.,Powell, B.,Shellooe, R.,Marimuthu, A.,Nguyen, H.,Zhang, K.Y.,Artis, D.R.,Schlessinger, J.,Su, F.,Higgins, B.,Iyer, R.,D'Andrea, K.,Koehler, A.,Stumm, M.,Lin, P.S.,Lee, R.J.,Grippo, J.,Puzanov, I.,Kim, K.B.,Ribas, A.,McArthur, G.A.,Sosman, J.A.,Chapman, P.B.,Flaherty, K.T.,Xu, X.,Nathanson, K.L.,Nolop, K.; Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.; Nature, 467:596-599, 2010; PubMed: 20823850; DOI: 10.1038/nature09454

Experimental method

X-RAY DIFFRACTION (2.45 Å)