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3OE8

Crystal structure of the CXCR4 chemokine receptor in complex with a small molecule antagonist IT1t in P1 spacegroup

Summary for 3OE8
Entry DOI10.2210/pdb3oe8/pdb
Related3ODU 3OE0 3OE6 3OE9
DescriptorC-X-C chemokine receptor type 4, Lysozyme Chimera, (6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylimidothiocarbamate (2 entities in total)
Functional Keywordsstructural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d, 7tm, g protein-coupled receptor, gpcr, signal transduction, hydrolase, cancer, hiv-1 co-receptor, chemotaxis, chemokine, cxcl12, sdf1, isothiourea, chimera, t4l fusion, membrane protein, transmembrane, singnaling protein, psi-biology, gpcr network, signaling protein
Biological sourceHomo Sapiens
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Total number of polymer chains3
Total formula weight172108.36
Authors
Primary citationWu, B.,Chien, E.Y.,Mol, C.D.,Fenalti, G.,Liu, W.,Katritch, V.,Abagyan, R.,Brooun, A.,Wells, P.,Bi, F.C.,Hamel, D.J.,Kuhn, P.,Handel, T.M.,Cherezov, V.,Stevens, R.C.
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.
Science, 330:1066-1071, 2010
Cited by
PubMed: 20929726
DOI: 10.1126/science.1194396
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.1 Å)
Structure validation

217705

数据于2024-03-27公开中

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