3OE8

Crystal structure of the CXCR4 chemokine receptor in complex with a small molecule antagonist IT1t in P1 spacegroup

3OE8 の概要

• エントリーDOI: 10.2210/pdb3oe8/pdb
• 関連するPDBエントリー: 3ODU 3OE0 3OE6 3OE9
• 分子名称: C-X-C chemokine receptor type 4, Lysozyme Chimera, (6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylimidothiocarbamate (2 entities in total)
• 機能のキーワード: structural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d, 7tm, g protein-coupled receptor, gpcr, signal transduction, hydrolase, cancer, hiv-1 co-receptor, chemotaxis, chemokine, cxcl12, sdf1, isothiourea, chimera, t4l fusion, membrane protein, transmembrane, singnaling protein, psi-biology, gpcr network, signaling protein
• 由来する生物種: Homo Sapiens; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 172108.36

構造登録者

Wu, B.,Mol, C.D.,Han, G.W.,Katritch, V.,Chien, E.Y.T.,Liu, W.,Cherezov, V.,Stevens, R.C.,Accelerated Technologies Center for Gene to 3D Structure (ATCG3D),GPCR Network (GPCR) (登録日: 2010-08-12, 公開日: 2010-10-27, 最終更新日: 2021-10-06)

• 主引用文献: Wu, B.,Chien, E.Y.,Mol, C.D.,Fenalti, G.,Liu, W.,Katritch, V.,Abagyan, R.,Brooun, A.,Wells, P.,Bi, F.C.,Hamel, D.J.,Kuhn, P.,Handel, T.M.,Cherezov, V.,Stevens, R.C.; Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.; Science, 330:1066-1071, 2010; PubMed: 20929726; DOI: 10.1126/science.1194396

実験手法

X-RAY DIFFRACTION (3.1 Å)